乐民实验室

郑乐民教授

(联系方式:Email: zhengl@bjmu.edu.cn; Tel: 010-82805452)


北京大学心血管研究所副所长,全国重点实验室主任助理,北京大学基础医学院党委委员,基础医学院心脑血管和代谢学科群副主任。国家“万人计划”科技创新领军人才(万人);国家“优秀青年基金”获得者(优青2014);国家“万人计划”青年拔尖人才(青拔2015)。作为第一完成人获得2022年北京医学科技奖一等奖和2022年度北京市科学技术奖二等奖。心血管代谢与蛋白质组学研究室主任(PI),研究员,博士生导师,专业为心血管病理生理学。本科毕业于北京师范大学化学系,本科毕业后进入中国科学院理化所工作,2000年进入全美心脏科第一的美国克利夫兰医院(Cleveland Clinic)攻读临床生物分析化学博士。博士毕业后留克利夫兰医院所属生物医学公司工作。2007年作为“985”引进人才进入北京大学心血管所担任副教授、研究室主任;2014年担任博士生导师,并担任基础医学院党委委员;2015担任北京大学基础医学院研究员(正高),博士生导师,研究室主任;2018年担任心血管研究所副所长,重点实验室主任助理。现担任中华医学会心血管分会基础学组委员,中国心胸血管麻醉学会精准医学分会副秘书长,北京生理协会血管分会糖脂代谢组组长,中国药理学会心血管药理专业委员会委员,中国脂质与脂蛋白专业委员会委员。曾任中国研究型医院协会心血管循证和精准医学专业委员会副主任委员,中国脂质与脂蛋白专业委员会青年副主任委员。

主持国自然血管重大等7项国自然基金等,作为研究骨干参加科技部重大专项(4项),获“万人”,“优青”,“青拔”,教育部“新世纪人才”人才基金。博士期间获美国心脏协会“Pre-doctoral Fellowship Award”等。共发表SCI文章125篇,其中93篇SCI责任作者,SCI引用超5300次(h-index 37);Researchgate(https://www.researchgate.net/profile/Lemin-Zheng)。主要作者文章(通讯作者含共同通讯, 其中IF大于等于10分为23篇;IF大于等于20分为6篇)包括

1)心脑血管类:European Heart Journal (IF=39.3, 2021); Neuron(16.2, 2023)Nature Communications(IF=16.6, 2022); Advanced Science(IF=15.1, 2022, 2021); Cardiovascular Research(IF=10.8, 2021a, 2021b); Stroke2022, 2021); Circulation: Heart Failure(IF=9.7, 2021); Science Bulletin(IF=18.9, 2023); Signal transduction and targeted therapy(IF=39.3, 2023); European Heart Journal Open(2022); Arteriosclerosis, Thrombosis, and Vascular Biology(2019); Aging Cell(2018); Redox Biology(IF=11.4, 2021,2018,2017); Cell Death & Disease(2018); Journal of Clinical Investigation(IF=15.9, 2004, 一作)

2)代谢相关疾病类:Gastroenterology(IF=29.4, 2020); Cell Metabolism(IF=29, 2023); Diabetes(2021); Kidney International(IF=19.6, 2021)Molecular Cancer(IF= 37.3, 2014); Clinical Cancer Research(IF=11.5, 2012)

3)心脑血管转化研究:Advanced Materials (IF=29.4, 2020); Advanced Functional Materials (IF=19.0, 2020, 2017); Nano Letters(IF=10.8, 2021); Biosensors and Bioelectronics(IF=12.6, 2022)Nano Research(IF=9.9, 2020)

2010年发明专利通过了美国专利局以及欧洲专利局,2019-2022共获中国专利4项(第一发明人)。2014-2020获得临床医学检验试剂盒批号10项(首席科学家)。于2022年5月由Springer Nature出版社出版由本人主编的专著《HDL Metabolism and Diseases》。担任Frontiers in Cardiovascular Medicine(IF=5.8)副主编,担任Wiley杂志社View Medicine副主编, 担任Genes & Diseases (IF=7.2), Biology (IF=5.1), Cardiovascular Drugs and Therapy (IF=3.9), Cardiovascular & Hematological Disorders - Drug Targets, Lipid &Cardiovascular Research, 《中国心血管病研究》,《中国动脉硬化杂志》等杂志编委。并作为主编创办国际杂志Global Translational MedicineGTMhttps://www.accscience.com/journal/GTM)与Metabolism and Translational Medicine (MTM) (https://www.hksmp.com/journals/mtm/index)。


研究方向:

1.    代谢以及肠道菌群代谢对心脑血管疾病影响研究。代谢与心脑血管疾病研究密切相关,心脑血管疾病(包括心梗与中风)的发生发展与预后都有代谢的参与,代谢调控是基因与蛋白调控之后一个重要的研究领域。我们团队也先后发现了一些代谢分子以及相关蛋白对心脑血管疾病的新的病理生理机制与临床相关研究,其中包括琥珀酸代谢、能量代谢、脂代谢与脂蛋白等信号通路对于心脑血管系统的影响。肠道菌群是人体代谢的另一个重要来源,它存在着稳态与非稳态的平衡,这些平衡的打破能够带来不同的代谢物,由于这些代谢物的存在,从而影响到了肠道之外的其他器官,比如心脑血管系统等,从而产生了肠心轴、肠脑轴、肠肝轴等新的理论体系。我们团队发现了一系列新的肠道菌群代谢物例如TMAVA(三甲基-5-氨基戊酸)对心脏以及肝脏的病理生理作用,也发现了已经被大家熟知的TMAO(氧化三甲胺)新的病理生理功能比如在卒中与肺动脉高压中的新机制。

2.    代谢对其他相关疾病影响研究。代谢除了对心脑血管疾病产生巨大作用外,代谢性疾病也会影响到心脑血管疾病之外的疾病例如糖尿病。同时代谢方面的机制不但能影响到糖尿病肾病、脂肪肝等代谢性疾病,还能通过代谢通路影响到肿瘤中的血管新生以及肿瘤。通过代谢的干预以及代谢相关调控,我们能够对疾病的治疗提供新的思路与见解。

3.    结合新材料新技术开展心脑血管相关转化医学研究。心脑血管功能方面的应用,包括治疗与体外诊断技术的应用与研究。结合纳米技术与探针材料开展对心脑血管的诊断与治疗研究,对特定细胞例如炎症细胞等进行标记,对特定细胞进行药物运输,使得心脑血管的诊断与治疗能够在新赛道上继续发展。开展包括生物质谱技术在内的诊断学研究,将新的监测与诊断技术应用在心脑血管疾病的预防与预后上。


http://cn.leminlab.com/Article/20231113/20477.html


40篇代表SCI论文(*作为责任作者):

1.         Rui Zhan#, Xia Meng#, Dongping Tian, Jie Xu, Hongtu Cui, Jialei Yang, Yangkai Xu, Mingming Shi, Jing Xue, Weiwei Yu, Gaofei Hu, Ke Li, Xiaoxiao Ge, Qi Zhang, Mingming Zhao, Jianyong Du, Xin Guo, Wenli Xu, Yang Gao, Changyu Yao, Fan Chen, Yue Chen, Wenxin Shan, Yujie Zhu, Liang Ji, Bing Pan, Yan Yu, Wenguang Li, Xuyang Zhao, Qihua He, Xiaohui Liu, Yue Huang, Shengyou Liao, Bin Zhou, Dehua Chui, Y Eugene Chen, Zheng Sun, *Erdan Dong, *Yongjun Wang, *Lemin Zheng. NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. Neuron. 2023 Aug 29:S0896-6273(23)00622-0. (IF=16.2JCRQ1)

2.         Pengxiang Qu#, Oren Rom#, Ke Li#, Linying Jia, Xiaojing Gao, Zhipeng Liu, Shusi Ding, Mingming Zhao, Huiqing Wang, Shuangshuang Chen, Xuelian Xiong, Ying Zhao, Chao Xue, Yang Zhao, Chengshuang Chu, Bo Wen, Alexandra C. Finney, Zuowen Zheng, Wenbin Cao, Jinpeng Zhao, Liang Bai, Sihai Zhao, Duxin Sun, Rong Zeng, Jiandie Lin, Wanqing Liu, *Lemin Zheng, *Jifeng Zhang, *Enqi Liu, Y. *Eugene Chen. DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates. Cell Metabolism. 2023, April 10, ISSN 1550-4131. (IF=29JCRQ1)

3.         Zekun Wang#, Nana Yang#, Yajun Hou, Yuqing Li, Chenyang Yin, Endong Yang, Huanhuan Cao, Gaofei Hu, Jing Xue, Jialei Yang, Ziyu Liao, Weiyun Wang, *Dongdong Sun, *Cundong Fan, *Lemin Zheng. L-Arginine-Loaded Gold Nanocages Ameliorate Myocardial Ischemia/Reperfusion Injury by Promoting Nitric Oxide Production and Maintaining Mitochondrial Function. Advanced science (Weinh). 2023 Sep;10(26):e2302123. (IF=15.1JCRQ1)

4.         Jianing Gao#, Huanhuan Cao, Gaofei Hu, Yufei Wu, Yangkai Xu, Hongtu Cui, Hong S Lu, *Lemin Zheng. The mechanism and therapy of aortic aneurysms. Signal transduction and targeted therapy. 2023 Feb 3;8(1):55. (IF=39.3JCRQ1)

5.         Qingyuan Liu#, Ke Li#, Hongwei He, Zengli Miao, Hongtu Cui, Jun Wu, Shusi Ding, Zheng Wen, Jiyuan Chen, *Xiaojie Lu, *Jiangan Li, *Lemin Zheng, *Shuo Wang. The markers and risk stratification model of intracranial aneurysm instability in a large Chinese cohort. Science bulletin. 2023 May 10:S2095-9273(23)00308-0. (IF=18.9JCRQ1)

6.         Jianing Gao#, Yanghui Chen#, Huiqing Wang, Xin Li, Ke Li, Yangkai Xu, Xianwei Xie, Yansong Guo, Nana Yang, Xinhua Zhang, Dong Ma, Hong S Lu, Ying H Shen, Yong Liu, Jifeng Zhang, Y Eugene Chen, Alan Daugherty, *Dao Wen Wang, *Lemin Zheng. Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis. Advanced Science (Weinh). 2022 Dec 25:e2204038. (IF=15.1JCRQ1)

7.         Huanhuan Cao, Yujie Zhu, Gaofei Hu, Qi Zhang, *Lemin Zheng. Gut microbiome and metabolites, the future direction of diagnosis and treatment of atherosclerosis? Pharmacological Research. 2023 Jan;187:106586. (IF=9.3JCRQ1)

8.         Mingming Zhao#, Haoran Wei#, Chenze Li, Rui Zhan, Changjie Liu, Jianing Gao, Yaodong Yi, Xiao Cui, Wenxin Shan, Liang Ji, Bing Pan, Si Cheng, Moshi Song, Haipeng Sun, Huidi Jiang, Jun Cai, Minerva Garcia-Barrio, Y. Eugene Chen, Xiangbao Meng, Erdan Dong, *Dao Wen Wang, *Lemin Zheng. Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy. Nature Communications. 2022 Apr 1;13(1):1757. (IF=16.6JCRQ1)

9.         Yang Y#, Zeng Q#, Gao J#, Yang B, Zhou J, Li K, Li L, Wang A, Li X, Liu Z, Luo Q, Zhao Z, Liu B, Xue J, Jiang X, Konerman MC, *Zheng Lemin, *Xiong C. High-circulating gut microbiota-dependent metabolite trimethylamine N-oxide is associated with poor prognosis in pulmonary arterial hypertension. European Heart Journal Open. 2022 Mar 29;2(5):oeac021.

10.     Xu J#, Hao X#, Zhan R#, Jiang X, Jin A, Xue J, Cheng A, Liu J, Lin J, Meng X, Li H, *Zheng L, *Wang Y. Effect of Lipoprotein(a) on Stroke Recurrence Attenuates at Low LDL-C (Low-Density Lipoprotein) and Inflammation Levels. Stroke. 2022 Apr 12:101161STROKEAHA121034924. (JCRQ1)

11.     Xiao-Xiao Chen#, Yufei Wu#, Xiaoxiao Ge, Liandi Lei, *Li-Ya Niu, *Qing-Zheng Yang, *Lemin Zheng. In vivo imaging of heart failure with preserved ejection fraction by simultaneous monitoring of cardiac nitric oxide and glutathione using a three-channel fluorescent probe. Biosensors and Bioelectronics. Volume 214, 2022, 114510, ISSN 0956-5663.IF=12.6JCRQ1

12.     Cui H#, Chen Y#, Li K, Zhan R, Zhao M, Xu Y, Lin Z, Fu Y, He Q, Tang PC, Lei I, Zhang J, Li C, Sun Y, Zhang X, Horng T, Lu HS, Chen YE, Daugherty A, *Wang D, *Lemin Zheng. Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection. European Heart Journal. 2021 Nov 7;42(42):4373-4385.  (IF=39.3JCRQ1)

13.     Jiang X, Xu J, Hao X, Xue J, Li K, Jin A, Lin J, Meng X, *Zheng L, *Wang Y. Elevated lipoprotein(a) and lipoprotein-associated phospholipase A2 are associated with unfavorable functional outcomes in patients with ischemic stroke. Journal of Neuroinflammation. 2021 Dec 28;18(1):307. (IF=9.3JCRQ1)

14.     Xu J#, Zhao M#, Wang A, Xue J, Cheng S, Cheng A, Gao J, Zhang Q, Zhan R, Meng X, Xu M, Li H, Zheng L*, Wang Y*. Association Between Plasma Trimethyllysine and Prognosis of Patients With Ischemic Stroke. Journal of the American Heart Association. 2021 Dec 7;10(23):e020979.

15.     Xu J#, Cheng A#, Song B, Zhao M, Xue J, Wang A, Dai L, Jing J, Meng X, Li H, *Zheng L, *Wang Y. Trimethylamine N-Oxide and Stroke Recurrence Depends on Ischemic Stroke Subtypes. Stroke. 2021 Nov 19:STROKEAHA120031443. (JCRQ1)

16.     Li C#, Zhao M#, Xiao L, Wei H, Wen Z, Hu D, Yu B, Sun Y, Gao J, Shen X, Zhang Q, Cao H, Huang J, Huang W, Li K, Huang M, Ni L, Yu T, Ji L, Xu Y, Liu G, Konerman MC, *Lemin Zheng, *Wang D. Prognostic Value of Elevated Levels of Plasma N-Acetylneuraminic Acid in Patients With Heart Failure. Circulation: Heart Failure. 2021 Nov;14(11):e008459 IF=9.7JCRQ1

17.     Wu L#, Liu C#, Chang D Y, Zhan R, Zhao M, Lam S M, Shui G, Zhao M H, *Lemin Zheng, *Chen M. The attenuation of diabetic nephropathy by annexin A1 via regulation of lipid metabolism through AMPK/PPARα/CPT1b pathway. Diabetes. 2021 Oct;70(10):2192-2203. (JCRQ1)

18.     Wei H#, Zhao M#, Huang M, Li C, Gao J, Yu T, Zhang Q, Shen X, Ji L, Ni L, Zhao C, Wang Z, Dong E, Zheng L*, Wang DW*. FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population. Frontiers of Medicine. 2021 Jun 22. JCRQ1

19.     Zhou C, Lin Z, Cao H, Chen Y, Li J, Zhuang X, Ma D, Ji L, Li W, Xu S, *Pan B, *Lemin Zheng. Anxa1 in smooth muscle cells protects against acute aortic dissection. Cardiovascular Research. 2021 Mar 23:cvab109. (IF=10.8JCRQ1)

20.     Jingxuan Li#, Yingyu Chen#, Jianing Gao, Yue Chen, Changping Zhou, Xin Lin, Changjie Liu, Mingming Zhao, Yangkai Xu, Liang Ji, Zongzhe Jiang, *Bing Pan, *Lemin Zheng. Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b. Cardiovascular Research. 2021 Jan 21;117(2):450-461. (IF=10.8JCRQ1)

21.     Man Z, Cui H, Lv Z, Xu Z*, Wu Z, Wu Y, Liao Q, Liu M, Xi P*, Zheng L*, Fu H*. Organic Nanoparticles-Assisted Low-Power STED Nanoscopy. Nano Letters. 2021 Apr 28;21(8):3487-3494. (IF=10.8JCRQ1)

22.     Wu L#, Liu C#, Chang DY, Zhan R, Sun J, Cui SH, Eddy S, Nair V, Tanner E, Brosius FC, Looker HC, Nelson RG, Kretzler M, Wang JC, Xu M, Ju W, Zhao MH, *Chen M, *Lemin Zheng. Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy. Kidney International. 2021 Jul;100(1):107-121. (IF=19.6JCRQ1)

23.     Zhang M#, Gao J#, Zhao X, Zhao M, Ma D, Zhang X, Tian D, Pan B, Yan X, Wu J, Meng X, Yin H, *Lemin Zheng. p38α in macrophages aggravates arterial endothelium injury by releasing IL-6 through phosphorylating megakaryocytic leukemia 1. Redox Biology. 2021 Jan;38:101775. (IF=11.4JCRQ1)

24.     Jian Kong#, Changyu Yao#, Shuying Dong#, Shilun Wu, Yangkai Xu, Ke Li, Liang Ji, Qiang Shen, Qi Zhang, Rui Zhan, Hongtu Cui, Changping Zhou, Haigang Niu, Guoming Li, *Wenbing Sun, *Lemin Zheng. ICAM-1 Activates Platelets and Promotes Endothelial Permeability through VE-cadherin after Insufficient Radiofrequency Ablation. Advanced Science (Weinh). 2021 Jan 4;8(4):2002228. (IF=15.1JCRQ1)

25.     Mingming Zhao#, Lin Zhao#, Xuelian Xiong, Yuan He, Wei Huang, Zihao Liu, Liang Ji, Bing Pan, Xuefeng Guo, Leibo Wang, Si Cheng, Ming Xu, Hongyuan Yang, Yuxin Yin, Minerva T. Garcia-Barrio, Y. Eugene Chen, Xiangbao Meng, *Lemin Zheng. TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice. Gastroenterology. 2020 Jun;158(8):2266-2281. (IF=29.4JCRQ1)

26.     Xiaoxiao Ge#, Hongtu Cui#, Jian Kong, Shi-Yu Lu, Rui Zhan, Jianing Gao, Yangkai Xu, Shuangyan Lin, Kaixin Meng, Lingyun Zu, Shaojun Guo, *Lemin Zheng. A Non-Invasive Nanoprobe for In Vivo Photoacoustic Imaging of Vulnerable Atherosclerotic Plaque. Advanced Materials. 2020 Sep;32(38):e2000037.  (IF=29.4JCRQ1)

27.     Zheng Lv#, Zhongwei Man#, Hongtu Cui, Zhenzhen Xu*, Huanhuan Cao, Shuai Li, Qing Liao, Qihua He, Lemin Zheng*, and Hongbing Fu*. Red AIE Luminogens with Tunable Organelle Specific Anchoring for Live Cell Dynamic Super Resolution Imaging. Advanced Functional Materials. 2020, 31(10), 2009329. (IF=19.0JCRQ1)

28.     Zheng Lv #, Li Li#, Zhongwei Man, Zhenzhen Xu*, Hongtu Cui, Rui Zhan, Qihua He, *Lemin Zheng, Hongbing Fu*. Polarity-activated super-resolution imaging probe for the formation and morphology of amyloid fibrils. Nano Research. 2020, 13(9): 2556-2563. (IF=9.9JCRQ1)

29.     Jianping Li#, Changping Zhou#, Hongbing Xu#, Robert Brook, Shengcong Liu, Tieci Yi, Yang Wang, Baihuan Feng, Mingming Zhao, Xu Wang, Qian Zhao, Jie Chen, Xiaoming Song, Tong Wang, Shuo Liu, Yi Zhang, Rongshan Wu, Jianing Gao, Bing Pan, Subramaniam Pennathur, Sanjay Rajagopalan, Yong Huo, *Lemin Zheng, *Wei Huang. Ambient Air Pollution is Associated with High-Density Lipoprotein Dysfunction in Healthy Adults. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019 Mar;39(3):513-522. JCRQ1

30.     Man Z#, Lv Z#, *Xu Z, Cui H, Liao Q, Zheng Lemin*, Jin X, He Q, Fu H*. Organic nanoparticles with ultrahigh stimulated emission depletion efficiency for low-power STED nanoscopy. Nanoscale. 2019;11(27):12990-12996. (JCRQ1)

31.     He D#, Zhao M#, Wu C, Zhang W, Niu C, Yu B, Jin J, Ji L, Willard B, Mathew A, Chen Y, Pennathur S, Yin H, He Y, *Pan B, *Lemin Zheng. Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1. Redox Biology. 2018 May;15:228-242. (IF=11.4JCRQ1)

32.     Zhan R, Zhao M, Zhou T, Chen Y, Yu W, Zhao L, Zhang T, Wang H, Yang H, Jin Y, He Q, Yang X, Guo X, Willard B, Pan B, Huang Y, Chen Y, *Chui D, *Lemin Zheng. Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation. Cell Death & Disease. 2018 Jun 7;9(6):683. IF=9.0JCRQ1

33.     Li D#, Ke Y#, Zhan R, Liu C, Zhao M, Zeng A, Shi X, Ji L, Cheng S, Pan B, *Lemin Zheng, *Hong H. Trimethylamine-N-oxide promotes brain aging and cognitive impairment in mice. Aging Cell. 2018 Aug;17(4):e12768.  (JCRQ1)

34.     Ke Y#, Li D#, Zhao M, Liu C, Liu J, Zeng A, Shi X, Cheng S, Pan B, *Lemin Zheng, *Hong H. Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress. Free Radical Biology and Medicine. 2018 Jan 8;116:88-100. (JCRQ1)

35.     Lu J#, Chen B#, Chen T, Guo S, Xue X, Chen Q, Zhao M, Xia L, Zhu Z, *Lemin Zheng, *Yin H. Comprehensive metabolomics identified lipid peroxidation as a prominent feature in human plasma of patients with coronary heart diseases. Redox Biology. 2017 Aug;12:899-907. (IF=11.4JCRQ1)

36.     Feng C, *Xu Z, Wang X, Yang H, *Lemin Zheng, *Fu H. Organic-nanowire-SiO2 core-shell microlasers with highly polarized and narrow emissions for biological imaging. ACS Applied Materials & Interfaces. 2017.Mar 1;9(8):7385-7391. (IF=9.5JCRQ1)

37.     Zhang H, Wang X, Liao Q, Xu Z, Li H, *Lemin Zheng, *Fu H. Embedding Perovskite Nanocrystals into a Polymer Matrix for Tunable Luminescence Probes in Cell Imaging. Advanced Functional Materials. 2017 Feb;27(7):1604382. (IF=19.0JCRQ1)

38.     Kong J, Kong F, Gao J, Zhang Q, Dong S, Gu F, Ke S, Pan B, Shen Q, Sun H, *Lemin Zheng, Sun W*, YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Molecular Cancer. 2014 Jan 13;13:7. (IF=37.3JCRQ1)

39.     Pan B#, Ren H#, He Y, Lv X, Ma Y, Li J, Huang L, Yu B, Kong J, Niu C, Zhang Y, Sun WB, *Lemin Zheng. HDL of Patients with Type 2 Diabetes Mellitus Elevates the Capability of Promoting Breast Cancer Metastasis. Clinical Cancer Research. 2012 Mar 1;18(5):1246-56. (IF=11.5JCRQ1)

40.     Lemin Zheng, Nukuna B, Brennan M, Sun M, Goormastic M, Settle M, Schmitt D, Fu X, Thomson L, Fox P, Ischiropoulos H, Smith J, Kinter M, and Hazen S. Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. Journal of Clinical Investigation. 2004 Aug;114(4):529-41. (IF=15.9JCRQ1)



作为导师培养博士生(含共同导师)获奖

高佳宁(博士生, 2023,郑乐民为导师):北京大学“优博”。

吴靓  (博士生, 2022,郑乐民为共同导师):北京市“优博”;北京大学“优博”。

崔宏图(博士生, 2021,郑乐民为导师):北京市优秀毕业生;北大优秀毕业生;国家“博新计划博士后” 获得者。

赵明明(博士生, 2020,郑乐民为导师):北京市优秀毕业生;北京大学“优博”;北大优秀毕业生;国家“博新计划博士后”获得者。现为北大第三医院副研究员。




相关链接:

Researchgate(https://www.researchgate.net/profile/Lemin-Zheng

郑乐民_北京大学基础医学院 (bjmu.edu.cn)

郑乐民_北京大学心血管研究所 (bjmu.edu.cn)


公众号:乐民医学


抖音:Lemin Lab