乐民实验室

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郑乐民教授

（联系方式：Email: zhengl@bjmu.edu.cn; Tel: 010-82805452）

北京大学心血管研究所副所长，北京大学基础医学院党委委员，北大博雅特聘教授；全国重点实验室主任助理，基础医学院心脑血管和代谢学科群副主任。国家“万人计划”科技创新领军人才（万人2023）；国家“万人计划”青年拔尖人才（青拔2015）；国家“优秀青年基金”获得者（优青2014）；教育部“新世纪人才”人才基金。作为第一完成人获得2022年北京医学科技奖一等奖和2022年度北京市科学技术奖二等奖。主持国自然血管重大等7项国自然基金，作为项目负责人（2023）参加科技部重大专项等5项，主持北京市重点基金（2023）等3项与京津冀联合基金（2023）。

心血管代谢与蛋白质组学研究室主任（PI），教授，博士生导师，专业为心血管病理生理学。本科毕业于北京师范大学化学系，本科毕业后进入中国科学院理化所工作，2000年进入全美心脏科第一的美国克利夫兰医院（Cleveland Clinic）攻读临床生物分析化学博士。博士毕业后留克利夫兰医院所属生物医学公司工作。2007年作为“985”引进人才进入北京大学心血管所担任副教授、研究室主任；2014年担任博士生导师，并担任基础医学院党委委员；2015担任北京大学基础医学院研究员（正高），博士生导师；2018年担任心血管研究所副所长，重点实验室主任助理；2024年担任北大博雅特聘教授，新体制长聘正教授。现担任中华医学会心血管分会基础学组委员，中国心胸血管麻醉学会精准医学分会副秘书长，北京生理协会血管分会糖脂代谢组组长，中国药理学会心血管药理专业委员会委员，中国脂质与脂蛋白专业委员会委员。曾任中国研究型医院协会心血管循证和精准医学专业委员会副主任委员，中国脂质与脂蛋白专业委员会青年副主任委员。共发表SCI文章135篇，其中98篇SCI责任作者，SCI引用超6690次（h-index 39）；Researchgate（https://www.researchgate.net/profile/Lemin-Zheng）。主要作者文章（通讯作者含共同通讯, 其中IF大于等于10分为27篇；IF大于等于20分为9篇）包括：

1)心脑血管类：European Heart Journal (IF=37.6, 2021); Neuron（14.7, 2023）；Nature Communications（IF=14.7, 2022）; Advanced Science（IF=14.3, 2023, 2022, 2021）; Cardiovascular Research（IF=10.2, 2021a, 2021b）; Signal transduction and targeted therapy（IF=40.8, 2023）; Science Bulletin（IF=18.8, 2023）; iMeta(IF=23.7, 2024, 2023) ; Stroke（2022, 2021）; Circulation: Heart Failure（2021）; European Heart Journal Open（2022）; Arteriosclerosis, Thrombosis, and Vascular Biology（2019）; Aging Cell（2018）; Redox Biology（IF=10.7, 2021,2018,2017）; Cell Death & Disease（2018）。

2)代谢相关疾病类：Signal transduction and targeted therapy（IF=40.8, 2024）；Gastroenterology（IF=25.7, 2020）; Cell Metabolism（IF=27.7, 2023）; Kidney International（IF=14.8, 2021）; Diabetes（2021）; Molecular Cancer（IF= 27.7, 2014）; Clinical Cancer Research（IF=10, 2012）。

3)心脑血管转化医学研究：Advanced Materials （IF=27.4, 2020）; Advanced Functional Materials （IF=18.5, 2024, 2020, 2017）; Nano Letters（IF=9.6, 2021）; Biosensors and Bioelectronics（IF=10.7, 2022）；Nano Research（IF=9.5, 2020）。

2010年发明专利通过了美国专利局以及欧洲专利局，2019-2024共获中国专利5项（第一发明人）。2014-2020获得临床医学检验试剂盒批号10项（首席科学家）。于2022年由Springer Nature出版社出版由本人主编的英文专著《HDL Metabolism and Diseases》。担任Springer Nature杂志社SCI杂志Cardiovascular Drugs and Therapy副主编, SCI杂志Frontiers in Cardiovascular Medicine副主编，担任Wiley杂志社View Medicine副主编, 担任Genes & Diseases, Biology等SCI杂志编委。并作为主编创办国际杂志Global Translational Medicine（GTM）（https://www.accscience.com/journal/GTM）。

研究方向：

1. 代谢途径影响心脑血管稳态和疾病机制研究。心脏和血管功能稳态与其代谢状态密切相关，代谢途径广泛参与心脑血管疾病（如动脉瘤、心梗、卒中等）的发生发展，代谢调控是继基因调控、蛋白调控之后一个重要的研究领域。团队发现多种代谢分子和途径参与心血管疾病的新病理生理学机制及其中的关键靶点蛋白，包括巨噬细胞通过释放琥珀酸激活炎症反应；细胞连接蛋白Cx43通过调控NAD+水平维持脑血管内皮屏障功能稳态；在动脉瘤状态下平滑肌细胞GSDMD介导腐胺释放和表型转换；apo(a)等脂代谢与脂蛋白等信号通路影响心血管系统的新机制等。

2. 发现内源性和肠道菌群来源的新活性因子及其代谢调控作用。在心脑血管疾病相关人群样本中，我们通过多组学方法鉴定得到了多个活性因子，并发现其对代谢相关疾病如糖尿病、脂肪肝、肿瘤等的作用及机制。其中，我们证实内源性因子膜联蛋白A1在动脉夹层、糖尿病肾病和肥胖中作用于不同细胞类型并发挥了保护作用，血管内皮代谢调控了肿瘤中血管新生及肿瘤进展等。肠道菌群是人体代谢的另一个重要来源，疾病过程中肠道菌群紊乱产生的代谢谱变化又进一步影响了疾病进程，从而产生了肠心轴、肠脑轴、肠肝轴等新的理论体系。团队在首次鉴定得到新的肠道菌群代谢产物三甲基氨基戊酸（TMAVA）并阐明其加重脂肪肝和心脏肥大作用机制，也开发了针对重要肠道菌群活性代谢产物氧化三甲胺（TMAO）的质谱检测方法并发现其在卒中、肺动脉高压中的新病生理功能。通过代谢的干预以及代谢相关调控，我们对心脑血管疾病和代谢相关疾病的治疗提出了新的思路与见解。

3. 结合新材料新技术开展心脑血管相关诊断与治疗转化医学研究。应用新技术开发心脑血管疾病诊断和治疗方法，包括使用生物纳米材料搭载成像基团或药理成分实现动脉斑块等疾病的非侵入性成像或靶向治疗，使用分子探针和结构预测开发纠正疾病代谢紊乱的相关药物，优化临床质谱检测方法开发心脑血管疾病多指标综合预警体系等，助力心脑血管的诊断与治疗能够在新赛道上继续发展。

http://cn.leminlab.com/Article/20231113/20477.html

40篇代表SCI论文（*作为责任作者）：

1. Lu Fang^#, Changjie Liu^#, Zong-Zhe Jiang, Mengxiao Wang, Kang Geng, Yangkai Xu, Yujie Zhu, Yiwen Fu, Jing Xue, Wenxin Shan, Qi Zhang, Jie Chen, Jiahong Chen, Mingming Zhao, Yuxuan Guo, K W Michael Siu, Y Eugene Chen, *Yong Xu, *Donghui Liu, *Lemin Zheng. Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity. Signal transduction and targeted therapy. 2024 Aug 23;9(1):218. (IF=40.8，JCR：Q1)

2. Jiageng Cai^#, Xiaoxiao Ge^#, Shiyu Lu, Yabin Wang, Hongtu Cui, Rui Zhan, Sheng'e Su, Wenxin Shan, Zhulan Cai, Cencen Wu, Yuan Xu, Penghui Zhao, Yanyan Li, Yue Lan, Le Sun, *Shaojun Guo, *Lemin Zheng, *Lingyun Zu. Au/FeNiPO4-Based Multiple Spectra Optoacoustic Tomography/CT Dual-Mode Nanoprobe for Systemic Screening of Atherosclerotic Vulnerable Plaque. Advanced Functional Materials. 29 May 2024 https://doi.org/10.1002/adfm.202406192. (IF=18.5，JCR：Q1)

3. Yicheng Yang^#, Hanwen Zhang^#, Yaoyao Wang^#, Jing Xu^#, Songren Shu, Peizhi Wang , Shusi Ding, Yuan Huang, *Lemin Zheng, *Yuejin Yang, *Changming Xiong. Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota. iMeta. 2024 Jan 1;3(2):e159. (IF=23.7)

4. Jing Xu^#, Yicheng Yang^#, Xin Li^#, Shusi Ding, *Lemin Zheng, *Changming Xiong, *Yuejin Yang. Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases. iMeta. 2023 Jun 19;2(3):e124. (IF=23.7)

5. Rui Zhan^#, Xia Meng^#, Dongping Tian, Jie Xu, Hongtu Cui, Jialei Yang, Yangkai Xu, Mingming Shi, Jing Xue, Weiwei Yu, Gaofei Hu, Ke Li, Xiaoxiao Ge, Qi Zhang, Mingming Zhao, Jianyong Du, Xin Guo, Wenli Xu, Yang Gao, Changyu Yao, Fan Chen, Yue Chen, Wenxin Shan, Yujie Zhu, Liang Ji, Bing Pan, Yan Yu, Wenguang Li, Xuyang Zhao, Qihua He, Xiaohui Liu, Yue Huang, Shengyou Liao, Bin Zhou, Dehua Chui, Y Eugene Chen, Zheng Sun, *Erdan Dong, *Yongjun Wang, *Lemin Zheng. NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. Neuron. 2023 Aug 29:S0896-6273(23)00622-0. (IF=14.7，JCR：Q1)

6. Pengxiang Qu^#, Oren Rom^#, Ke Li^#, Linying Jia, Xiaojing Gao, Zhipeng Liu, Shusi Ding, Mingming Zhao, Huiqing Wang, Shuangshuang Chen, Xuelian Xiong, Ying Zhao, Chao Xue, Yang Zhao, Chengshuang Chu, Bo Wen, Alexandra C. Finney, Zuowen Zheng, Wenbin Cao, Jinpeng Zhao, Liang Bai, Sihai Zhao, Duxin Sun, Rong Zeng, Jiandie Lin, Wanqing Liu, *Lemin Zheng, *Jifeng Zhang, *Enqi Liu, Y. *Eugene Chen. DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates. Cell Metabolism. 2023, April 10, ISSN 1550-4131. (IF=27.7，JCR：Q1)

7. Zekun Wang^#, Nana Yang^#, Yajun Hou, Yuqing Li, Chenyang Yin, Endong Yang, Huanhuan Cao, Gaofei Hu, Jing Xue, Jialei Yang, Ziyu Liao, Weiyun Wang, *Dongdong Sun, *Cundong Fan, *Lemin Zheng. L-Arginine-Loaded Gold Nanocages Ameliorate Myocardial Ischemia/Reperfusion Injury by Promoting Nitric Oxide Production and Maintaining Mitochondrial Function. Advanced science (Weinh). 2023 Sep;10(26):e2302123. (IF=14.3，JCR：Q1)

8. Jianing Gao^#, Huanhuan Cao, Gaofei Hu, Yufei Wu, Yangkai Xu, Hongtu Cui, Hong S Lu, *Lemin Zheng. The mechanism and therapy of aortic aneurysms. Signal transduction and targeted therapy. 2023 Feb 3;8(1):55. (IF=40.8，JCR：Q1)

9. Qingyuan Liu^#, Ke Li^#, Hongwei He, Zengli Miao, Hongtu Cui, Jun Wu, Shusi Ding, Zheng Wen, Jiyuan Chen, *Xiaojie Lu, *Jiangan Li, *Lemin Zheng, *Shuo Wang. The markers and risk stratification model of intracranial aneurysm instability in a large Chinese cohort. Science bulletin. 2023 May 10:S2095-9273(23)00308-0. (IF=18.8，JCR：Q1)

10. Jianing Gao^#, Yanghui Chen^#, Huiqing Wang, Xin Li, Ke Li, Yangkai Xu, Xianwei Xie, Yansong Guo, Nana Yang, Xinhua Zhang, Dong Ma, Hong S Lu, Ying H Shen, Yong Liu, Jifeng Zhang, Y Eugene Chen, Alan Daugherty, *Dao Wen Wang, *Lemin Zheng. Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis. Advanced Science (Weinh). 2022 Dec 25:e2204038. (IF=14.3，JCR：Q1)

11. Huanhuan Cao, Yujie Zhu, Gaofei Hu, Qi Zhang, *Lemin Zheng. Gut microbiome and metabolites, the future direction of diagnosis and treatment of atherosclerosis? Pharmacological Research. 2023 Jan;187:106586. (JCR：Q1)

12. Mingming Zhao^#, Haoran Wei^#, Chenze Li, Rui Zhan, Changjie Liu, Jianing Gao, Yaodong Yi, Xiao Cui, Wenxin Shan, Liang Ji, Bing Pan, Si Cheng, Moshi Song, Haipeng Sun, Huidi Jiang, Jun Cai, Minerva Garcia-Barrio, Y. Eugene Chen, Xiangbao Meng, Erdan Dong, *Dao Wen Wang, *Lemin Zheng. Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy. Nature Communications. 2022 Apr 1;13(1):1757. (IF=14.7，JCR：Q1)

13. Yang Y^#, Zeng Q^#, Gao J^#, Yang B, Zhou J, Li K, Li L, Wang A, Li X, Liu Z, Luo Q, Zhao Z, Liu B, Xue J, Jiang X, Konerman MC, *Zheng Lemin, *Xiong C. High-circulating gut microbiota-dependent metabolite trimethylamine N-oxide is associated with poor prognosis in pulmonary arterial hypertension. European Heart Journal Open. 2022 Mar 29;2(5):oeac021.

14. Xu J^#, Hao X^#, Zhan R^#, Jiang X, Jin A, Xue J, Cheng A, Liu J, Lin J, Meng X, Li H, *Zheng L, *Wang Y. Effect of Lipoprotein(a) on Stroke Recurrence Attenuates at Low LDL-C (Low-Density Lipoprotein) and Inflammation Levels. Stroke. 2022 Apr 12:101161STROKEAHA121034924. (JCR：Q1)

15. Xiao-Xiao Chen^#, Yufei Wu^#, Xiaoxiao Ge, Liandi Lei, *Li-Ya Niu, *Qing-Zheng Yang, *Lemin Zheng. In vivo imaging of heart failure with preserved ejection fraction by simultaneous monitoring of cardiac nitric oxide and glutathione using a three-channel fluorescent probe. Biosensors and Bioelectronics. Volume 214, 2022, 114510, ISSN 0956-5663.（IF=10.7，JCR：Q1）

16. Cui H^#, Chen Y^#, Li K, Zhan R, Zhao M, Xu Y, Lin Z, Fu Y, He Q, Tang PC, Lei I, Zhang J, Li C, Sun Y, Zhang X, Horng T, Lu HS, Chen YE, Daugherty A, *Wang D, *Lemin Zheng. Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection. European Heart Journal. 2021 Nov 7;42(42):4373-4385. (IF=37.6，JCR：Q1)

17. Jiang X, Xu J, Hao X, Xue J, Li K, Jin A, Lin J, Meng X, *Zheng L, *Wang Y. Elevated lipoprotein(a) and lipoprotein-associated phospholipase A2 are associated with unfavorable functional outcomes in patients with ischemic stroke. Journal of Neuroinflammation. 2021 Dec 28;18(1):307. (IF=9.3，JCR：Q1)

18. Xu J^#, Zhao M^#, Wang A, Xue J, Cheng S, Cheng A, Gao J, Zhang Q, Zhan R, Meng X, Xu M, Li H, Zheng L*, Wang Y*. Association Between Plasma Trimethyllysine and Prognosis of Patients With Ischemic Stroke. Journal of the American Heart Association. 2021 Dec 7;10(23):e020979. (JCR：Q1)

19. Xu J^#, Cheng A^#, Song B, Zhao M, Xue J, Wang A, Dai L, Jing J, Meng X, Li H, *Zheng L, *Wang Y. Trimethylamine N-Oxide and Stroke Recurrence Depends on Ischemic Stroke Subtypes. Stroke. 2021 Nov 19:STROKEAHA120031443. (JCR：Q1)

20. Li C^#, Zhao M^#, Xiao L, Wei H, Wen Z, Hu D, Yu B, Sun Y, Gao J, Shen X, Zhang Q, Cao H, Huang J, Huang W, Li K, Huang M, Ni L, Yu T, Ji L, Xu Y, Liu G, Konerman MC, *Lemin Zheng, *Wang D. Prognostic Value of Elevated Levels of Plasma N-Acetylneuraminic Acid in Patients With Heart Failure. Circulation: Heart Failure. 2021 Nov;14(11):e008459 （JCR：Q1）

21. Wu L^#, Liu C^#, Chang D Y, Zhan R, Zhao M, Lam S M, Shui G, Zhao M H, *Lemin Zheng, *Chen M. The attenuation of diabetic nephropathy by annexin A1 via regulation of lipid metabolism through AMPK/PPARα/CPT1b pathway. Diabetes. 2021 Oct;70(10):2192-2203. (JCR：Q1)

22. Zhou C, Lin Z, Cao H, Chen Y, Li J, Zhuang X, Ma D, Ji L, Li W, Xu S, *Pan B, *Lemin Zheng. Anxa1 in smooth muscle cells protects against acute aortic dissection. Cardiovascular Research. 2021 Mar 23:cvab109. (IF=10.2，JCR：Q1)

23. Jingxuan Li^#, Yingyu Chen^#, Jianing Gao, Yue Chen, Changping Zhou, Xin Lin, Changjie Liu, Mingming Zhao, Yangkai Xu, Liang Ji, Zongzhe Jiang, *Bing Pan, *Lemin Zheng. Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b. Cardiovascular Research. 2021 Jan 21;117(2):450-461. (IF=10.2，JCR：Q1)

24. Man Z, Cui H, Lv Z, Xu Z*, Wu Z, Wu Y, Liao Q, Liu M, Xi P*, Zheng L*, Fu H*. Organic Nanoparticles-Assisted Low-Power STED Nanoscopy. Nano Letters. 2021 Apr 28;21(8):3487-3494. (IF=9.6，JCR：Q1)

25. Wu L^#, Liu C^#, Chang DY, Zhan R, Sun J, Cui SH, Eddy S, Nair V, Tanner E, Brosius FC, Looker HC, Nelson RG, Kretzler M, Wang JC, Xu M, Ju W, Zhao MH, *Chen M, *Lemin Zheng. Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy. Kidney International. 2021 Jul;100(1):107-121. (IF=14.8，JCR：Q1)

26. Zhang M^#, Gao J^#, Zhao X, Zhao M, Ma D, Zhang X, Tian D, Pan B, Yan X, Wu J, Meng X, Yin H, *Lemin Zheng. p38α in macrophages aggravates arterial endothelium injury by releasing IL-6 through phosphorylating megakaryocytic leukemia 1. Redox Biology. 2021 Jan;38:101775. (IF=10.7，JCR：Q1)

27. Jian Kong^#, Changyu Yao^#, Shuying Dong^#, Shilun Wu, Yangkai Xu, Ke Li, Liang Ji, Qiang Shen, Qi Zhang, Rui Zhan, Hongtu Cui, Changping Zhou, Haigang Niu, Guoming Li, *Wenbing Sun, *Lemin Zheng. ICAM-1 Activates Platelets and Promotes Endothelial Permeability through VE-cadherin after Insufficient Radiofrequency Ablation. Advanced Science (Weinh). 2021 Jan 4;8(4):2002228. (IF=14.3，JCR：Q1)

28. Mingming Zhao^#, Lin Zhao^#, Xuelian Xiong, Yuan He, Wei Huang, Zihao Liu, Liang Ji, Bing Pan, Xuefeng Guo, Leibo Wang, Si Cheng, Ming Xu, Hongyuan Yang, Yuxin Yin, Minerva T. Garcia-Barrio, Y. Eugene Chen, Xiangbao Meng, *Lemin Zheng. TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice. Gastroenterology. 2020 Jun;158(8):2266-2281. (IF=25.7，JCR：Q1)

29. Xiaoxiao Ge^#, Hongtu Cui^#, Jian Kong, Shi-Yu Lu, Rui Zhan, Jianing Gao, Yangkai Xu, Shuangyan Lin, Kaixin Meng, Lingyun Zu, Shaojun Guo, *Lemin Zheng. A Non-Invasive Nanoprobe for In Vivo Photoacoustic Imaging of Vulnerable Atherosclerotic Plaque. Advanced Materials. 2020 Sep;32(38):e2000037. (IF=27.4，JCR：Q1)

30. Zheng Lv^#, Zhongwei Man^#, Hongtu Cui, Zhenzhen Xu*, Huanhuan Cao, Shuai Li, Qing Liao, Qihua He, Lemin Zheng*, and Hongbing Fu*. Red AIE Luminogens with Tunable Organelle Specific Anchoring for Live Cell Dynamic Super Resolution Imaging. Advanced Functional Materials. 2020, 31(10), 2009329. (IF=18.5，JCR：Q1)

31. Zheng Lv ^#, Li Li^#, Zhongwei Man, Zhenzhen Xu*, Hongtu Cui, Rui Zhan, Qihua He, *Lemin Zheng, Hongbing Fu*. Polarity-activated super-resolution imaging probe for the formation and morphology of amyloid fibrils. Nano Research. 2020, 13(9): 2556-2563. (IF=9.5，JCR：Q1)

32. Jianping Li^#, Changping Zhou^#, Hongbing Xu^#, Robert Brook, Shengcong Liu, Tieci Yi, Yang Wang, Baihuan Feng, Mingming Zhao, Xu Wang, Qian Zhao, Jie Chen, Xiaoming Song, Tong Wang, Shuo Liu, Yi Zhang, Rongshan Wu, Jianing Gao, Bing Pan, Subramaniam Pennathur, Sanjay Rajagopalan, Yong Huo, *Lemin Zheng, *Wei Huang. Ambient Air Pollution is Associated with High-Density Lipoprotein Dysfunction in Healthy Adults. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019 Mar;39(3):513-522. （JCR：Q1）

33. Ke Y#, Li D#, Zhao M, Liu C, Liu J, Zeng A, Shi X, Cheng S, Pan B, *Lemin Zheng, *Hong H. Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress. Free Radical Biology and Medicine. 2018 Jan 8;116:88-100. (JCR：Q2)

34. He D^#, Zhao M^#, Wu C, Zhang W, Niu C, Yu B, Jin J, Ji L, Willard B, Mathew A, Chen Y, Pennathur S, Yin H, He Y, *Pan B, *Lemin Zheng. Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1. Redox Biology. 2018 May;15:228-242. (IF=10.7，JCR：Q1)

35. Zhan R, Zhao M, Zhou T, Chen Y, Yu W, Zhao L, Zhang T, Wang H, Yang H, Jin Y, He Q, Yang X, Guo X, Willard B, Pan B, Huang Y, Chen Y, *Chui D, *Lemin Zheng. Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation. Cell Death & Disease. 2018 Jun 7;9(6):683. （JCR：Q1）

36. Li D^#, Ke Y^#, Zhan R, Liu C, Zhao M, Zeng A, Shi X, Ji L, Cheng S, Pan B, *Lemin Zheng, *Hong H. Trimethylamine-N-oxide promotes brain aging and cognitive impairment in mice. Aging Cell. 2018 Aug;17(4):e12768. (JCR：Q1)

37. Lu J^#, Chen B^#, Chen T, Guo S, Xue X, Chen Q, Zhao M, Xia L, Zhu Z, *Lemin Zheng, *Yin H. Comprehensive metabolomics identified lipid peroxidation as a prominent feature in human plasma of patients with coronary heart diseases. Redox Biology. 2017 Aug;12:899-907. (IF=10.7，JCR：Q1)

38. Feng C, *Xu Z, Wang X, Yang H, *Lemin Zheng, *Fu H. Organic-nanowire-SiO2 core-shell microlasers with highly polarized and narrow emissions for biological imaging. ACS Applied Materials & Interfaces. 2017.Mar 1;9(8):7385-7391. (JCR：Q2)

39. Zhang H, Wang X, Liao Q, Xu Z, Li H, *Lemin Zheng, *Fu H. Embedding Perovskite Nanocrystals into a Polymer Matrix for Tunable Luminescence Probes in Cell Imaging. Advanced Functional Materials. 2017 Feb;27(7):1604382. (IF=18.5，JCR：Q1)

40. Kong J, Kong F, Gao J, Zhang Q, Dong S, Gu F, Ke S, Pan B, Shen Q, Sun H, *Lemin Zheng, Sun W*, YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Molecular Cancer. 2014 Jan 13;13:7. (IF=27.7，JCR：Q1)

作为导师培养博士生（含共同导师）获奖：

高佳宁（博士生, 2023，郑乐民为导师）：北京大学“优博”。

吴靓（博士生, 2022，郑乐民为共同导师）：北京市“优博”；北京大学“优博”。

崔宏图（博士生, 2021，郑乐民为导师）：北京市优秀毕业生；北大优秀毕业生；国家“博新计划博士后” 获得者。

姚常玉（博士生，2021，郑乐民为共同导师）: 北京市“优博”；首都医科大学“优博”。

赵明明（博士生, 2020，郑乐民为导师）：北京市优秀毕业生；北京大学“优博”；北大优秀毕业生；国家“博新计划博士后”获得者。现为北大第三医院副研究员。